Connect two devices with different subnets

I have a problem where I need to connect one system to another that exist on different networks. How do I do this. I have tried using this NAT configuration: iptables -t nat -I PREROUTING -d 192.168.1.10 -j DNAT --to-destination 192.168.2.80 iptables -t nat -I POSTROUTING -s 192.168.2.80 -j SNAT --to-source 192.168.1.10 But I get no response when I ping 192.168.1.10 . SYSTEM_A IP: 192.168.2.80 SYSTEM_B IP: 192.168.1.123 I want to connect SYSTEM_A and SYSTEM_B but I can't get it to work, I have a Teltonika RUT300 router.

Question by Jacob on Super User, licensed CC BY-SA. We show a short excerpt and link to the original thread as credit.