Can 2 people use Windows 10 at the same time, play with a controller, work with keyboard and mouse?

I have multiple monitors and a strong PC with 2 sets of keyboards and mice and a game controller. What I want to achieve is that I can work while my wife plays a game at the same time. She'd play on one screen and I can work on another. The problem is if I use my keyboard and mouse the game recognises it as the new main input device. Another problem can be that some games need to be the active window in order to work (I believe some other don't have to be, they can work in borderless window mode or some other). My question is, is it possible to separate different input and run 2 separate insta

Question by Adam on Super User, licensed CC BY-SA. We show a short excerpt and link to the original thread as credit.