How to run imwheel at startup/login to allow scrolling while moving the mouse

Tl;dr: Moving the mouse while rotating the scroll wheel prevents the scrolling from actually happening in most applications. imwheel helps, but how do I run it on startup or login so that it actually works? In detail: I have a Windows 10 host and an Ubuntu 20.04 guest. The guest was originally installed in VMware, but I exported it (via an OVF) to VirtualBox too, for testing. In VMware Player I am using the not optimized for gaming mouse setting. I have two physical mouses attached. One is the normal mouse that controls the host OS ( Host-Mouse ). The other is passed through to the guest OS (

Question by Niko O on Super User, licensed CC BY-SA. We show a short excerpt and link to the original thread as credit.